BODYDRAIN

Bodydrain is a biologically active phytotherapeutic complex, with draining (orthosiphon and dandelion), cardiotonic (hawthorn) and metabolic energizing (garcinia and quercetin) actions and with chromium that acts as an enzyme activator and stimulates enzymes involved in glucose metabolism and energy metabolism in general.

The phytotherapeutic complex is completed by silymarin, a molecule that protects the liver, restores liver functions and stimulates protein synthesis. A particularly balanced formulation that promotes the physiological purifying process in the body, and is indicated in particular for the treatment of the pathophysiology of water retention in postoperative edema and panniculopathies. Useful to improve the conditions of alteration of the lymphatic vascular system and to support the physiological function of the lymphatic endothelium. and treatment of the pathophysiology of water retention, promoting fluid drainage.

Edema is a pathological condition of the microcirculation caused by an accumulation of fluid in the interstitial space. The appearance of edema and tissue swelling is common after surgery and is a major cause of postoperative pain. Cellulite is also caused by an alteration of the microcirculation and water retention.  Bodydrain is an association of a series of complexes of plant origin that reduce water retention and improve the microcirculation. The active ingredients present improve the elasticity of the venous walls and their tonicity, and decrease capillary permeability, resulting useful to improve the conditions of alteration of the lymphatic vascular system and to support the physiological function of the lymphatic endothelium.

Garcinia fruits extract. The titrated extract of Garcinia fruits has an anti-inflammatory and anti-edemigenous action. It also performs an important activator function, several pharmacological and clinical studies show the activity of the extract on the reduction of body weight and on a variety of parameters characteristic of the metabolic syndrome. Hydroxycitric acid, contained at 60% in the garcinia extract used in Bodydrain, is able to block the synthesis of acetyl coenzyme A (acetyl-CoA), an energetic substrate used by the body for the synthesis of cholesterol and other lipidimetabolico and is useful to address the emerging global epidemic of obesity: hyperlipidemia, insulin resistance and their co-morbid conditions. Hence its theoretically positive effect in slimming and restoring physiological lipemia. An aid in weight control could also derive from the presumed anorectic properties of garcinia, which translate into a reduction of appetite through the modulation of serotonin levels. ^1-4

Orthosiphon stamineus or Java Tea. It is known for its diuretic5 and purifying action and is widely used in all cases in which you want to promote the elimination of water, nitrogenous waste and uric acid through the urine^6,7.

Dandelion. Dandelion root has depurative properties, as it stimulates biliary, hepatic and renal function by activating the excretory organs (liver, kidney, skin) used for the transformation and elimination of toxins (feces, urine, sweat). The main components of its phytocomplex have depurative, anti-inflammatory and detoxifying properties for the liver: they promote the elimination of waste (sugars, triglycerides, cholesterol and uric acids), making dandelion extract a powerful hepatoprotective, indicated in case of liver failure, jaundice and gallstones. It also stimulates diuresis by favoring the elimination of excess liquids. Therefore, its assumption is indicated in case of water retention, cellulite and hypertension^8,9.

Hawthorn. Hawthorn or Crataegus oxyacantha is a shrub very common in temperate areas of northern hemisphere, of which berries and leaves are used; it contains crategolic acid, flavonoid pigments, glycosides, anthocyanins and terpenic derivatives.  This plant has a marked affinity for the heart, mainly related to active polyphenolic compounds: hawthorn has cardiotonic, antiarrhythmic, coronary dilatant, draining and hypotensive properties10. opic positive and hypotensive and can interfere with digitalis therapies.

Silymarin. It is a powerful antioxidant and supports digestive and hepatic function and promotes the body’s purifying functions^11,12.

Chromium.  Chromium is one of 13 trace elements recognized as necessary for the human body.

From a metabolic point of view, chromium seems to be able to enhance the actions of insulin by being part of the so-called glucose tolerance factor, a low molecular weight substance that – by binding to insulin and its receptor – would start that cascade of intracellular events leading to the migration of the pool of glucose transporters from the cytoplasm to the cell membrane. In diabetic patients, it increases sensitivity to insulin by improving glucose tolerance ¹³, chronic chromium deficiency reduces immune defenses¹⁴.

Bodydrain useful for:

Pathophysiological states that require an increase in draining activity

• localized and generalized edema
• hypertension
• gout
• intoxication from drugs and foods
• restrictive diets

Alterations in the subcutaneous connective tissue

• hypotonia
• hypotrophy
• aging

Alterations in carbohydrate and lipid metabolism

• hyperglycemia
• insulin resistance
• type 2 diabetes mellitus
• metabolic syndrome

Bone tissue alterations

• osteoporosis

1. Huang, P. L. (2009). A comprehensive definition for metabolic syndrome. Disease models & mechanisms, 2(5-6), 231-237.12 Kobayashi M, Matsui-Yuasa I, Fukuda-Shimizu M, Mandai.
2. Igho, O., Kang, H. S., Rachel, P., & Edzard, E. (2010). The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Journal of Obesity, 2011.
3. Sethi, A. (2011). A review on “Garcinia cambogia-a weight controlling agent”. Int J Pharm res dev, 3, 13-24.
4. Swami, S. B., Thakor, N. J., & Patil, S. C. (2014). Kokum (Garcinia indica) and its many functional components as related to the human health: a review. Journal of food research and technology, 2(4), 130-142.
5. Adam, Y., Somchit, M. N., Sulaiman, M. R., Nasaruddin, A. A., Zuraini, A., Bustamam, A. A., & Zakaria, Z. A. (2009). Diuretic properties of Orthosiphon stamineus Benth. Journal of Ethnopharmacology, 124(1), 154-158.
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8. Choi, U. K., Lee, O. H., Yim, J. H., Cho, C. W., Rhee, Y. K., Lim, S. I., & Kim, Y. C. (2010). Hypolipidemic and antioxidant effects of dandelion (taraxacum officinale) root and leaf on cholesterol-fed rabbits. International journal of molecular sciences, 11(1), 67-78.
9. Choi, U. K., Lee, O. H., Yim, J. H., Cho, C. W., Rhee, Y. K., Lim, S. I., & Kim, Y. C. (2010). Hypolipidemic and antioxidant effects of dandelion (taraxacum officinale) root and leaf on cholesterol-fed rabbits. International journal of molecular sciences, 11(1), 67-78.
10. Orhan, I. E. (2018). Phytochemical and pharmacological activity profile of Crataegus oxyacantha L.(hawthorn)-A cardiotonic herb. Current medicinal chemistry, 25(37), 4854-4865.
11. Bahmani, M., Shirzad, H., Rafieian, S., & Rafieian-Kopaei, M. (2015). Silybum marianum: beyond hepatoprotection. Journal of evidence-based complementary & alternative medicine, 20(4), 292-301.
12. Freitag, A. F., Cardia, G. F. E., da Rocha, B. A., Aguiar, R. P., Silva-Comar, F. M. D. S., Spironello, R. A., … & Cuman, R. K. N. (2015). Hepatoprotective effect of silymarin (Silybum marianum) on hepatotoxicity induced by acetaminophen in spontaneously hypertensive rats. Evidence-Based Complementary and Alternative Medicine, 2015.
13. Sala, M., Breithaupt, L., Bulik, C. M., Hamer, R. M., La Via, M. C., & Brownley, K. A. (2017). A double-blind, randomized pilot trial of chromium picolinate for overweight individuals with binge-eating disorder: effects on glucose regulation. Journal of dietary supplements, 14(2), 191-199.
14. Orhan, C., Kucuk, O., Tuzcu, M., Sahin, N., Komorowski, J. R., & Sahin, K. (2019). Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high‐fat diet. Food science & nutrition, 7(1), 183-194.